Berberine prevents primary peritoneal adhesion and adhesion reformation by directly inhibiting TIMP-1
نویسندگان
چکیده
منابع مشابه
Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats.
Intestinal adhesion, characterized by connection of the loops of the intestine with other abdominal organs by fibrous tissue bands, remains an inevitable event of abdominal operations and can cause a number of complications. Berberine hydrochloride (berberine), a natural plant alkaloid derived from Chinese herbal medicine, is characterized by diverse pharmacological effects, such as anticancer ...
متن کاملBerberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Ratss
Intestinal adhesion, characterized by connection of the loops of the intestine with other abdominal organs by fibrous tissue bands, remains an inevitable event of abdominal operations and can cause a number of complications. Berberine hydrochloride (berberine), a natural plant alkaloid derived from Chinese herbal medicine, is characterized by diverse pharmacological effects, such as anticancer ...
متن کاملMethylene Blue Prevents Post-Surgical Adhesion Formation in the Rabbit
Peritoneal adhesions are challenging in abdominal surgery. In spite of different kinds of treatments still no definitive and effective treatment is suggested. To determine the prevention effects of intraperitoneal (ip) methylene blue in post surgical adhesion formation 44 rabbits were randomly divided in two groups of equal number. Group I received an intra peritoneal injection of a 1% suspensi...
متن کاملCytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
OBJECTIVES Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface adhesion molecule involved in the recruitment of leukocytes to endothelial cells on arterial walls during the pathogenesis of atherosclerosis. The soluble ectodomain of VCAM-1 (sVCAM-1) is proteolytically released from the cell surface into the circulation, a process which is up-regulated in patients with cardiovascular or ...
متن کاملPeritoneal repair and post-surgical adhesion formation.
It was shown in 1919 that peritoneal healing differs from that of skin. When a defect is made in the parietal peritoneum the entire surface becomes epithelialized simultaneously and not gradually from the borders as in epidermalization of skin wounds. While multiplication and migration of mesothelial cells from the margin of the wound may play a small part in the regenerative process, it cannot...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2020
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2020.02.003